Resuscitation Science Intra-Arrest Transnasal Evaporative Cooling A Randomized, Prehospital, Multicenter Study (PRINCE: Pre-ROSC IntraNasal Cooling Effectiveness)

نویسندگان

  • Maaret Castrén
  • Fabio Taccone
چکیده

Maaret Castrén, MD, PhD*; Per Nordberg, MD*; Leif Svensson, MD, PhD; Fabio Taccone, MD; Jean-Louise Vincent, MD, PhD; Didier Desruelles, MD; Frank Eichwede, MD; Pierre Mols, MD, PhD; Tilmann Schwab, MD; Michel Vergnion, MD; Christian Storm, MD; Antonio Pesenti, MD, PhD; Jan Pachl, MD, PhD; Fabien Guérisse, MD; Thomas Elste, MD; Markus Roessler, MD, DEAA; Harald Fritz, MD; Pieterjan Durnez, MD; Hans-Jörg Busch, MD; Becky Inderbitzen, MSE; Denise Barbut, MD

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Intra-arrest transnasal evaporative cooling: a randomized, prehospital, multicenter study (PRINCE: Pre-ROSC IntraNasal Cooling Effectiveness).

BACKGROUND Transnasal evaporative cooling has sufficient heat transfer capacity for effective intra-arrest cooling and improves survival in swine. The aim of this study was to determine the safety, feasibility, and cooling efficacy of prehospital transnasal cooling in humans and to explore its effects on neurologically intact survival to hospital discharge. METHODS AND RESULTS Witnessed cardi...

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Although targeted temperature management (TTM) has been widely implemented among comatose survivors after cardiac arrest (CA), there are still several unanswered issues, including the optimal time to initiate cooling. Experimental studies have showed that early cooling after return of spontaneous circulation (ROSC) provides better neurological protection than normothermia, while clinical studie...

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Introduction Trans-nasal cooling started during cardiopulmonary resuscitation (CPR) has shown to improve the return to spontaneous circulation (ROSC) and survival rate in an experimental prolonged cardiac arrest model. A multicenter randomized trial (PRINCE) has also suggested an improved neurological outcome in patients receiving trans-nasal cooling during CPR in the prehospital setting when c...

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AIMS OF STUDY We have previously demonstrated that early intra-nasal cooling improved post-resuscitation neurological outcomes. The present study utilizing a porcine model of prolonged cardiac arrest investigated the effects of intra-nasal cooling initiated at the start of cardiopulmonary resuscitation (CPR) on resuscitation success. Our hypothesis was that rapid nasal cooling initiated during ...

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BACKGROUND Recent clinical studies have demonstrated that hypothermia to 32 degrees to 34 degrees C provides significant clinical benefit when induced after resuscitation from cardiac arrest. However, cooling during the postresuscitation period was slow, requiring 4 to 8 hours to achieve target temperatures after return of spontaneous circulation (ROSC). Whether more rapid cooling would further...

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تاریخ انتشار 2010